The anion exchanger Ae2 is required for enamel maturation in mouse teeth
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چکیده
منابع مشابه
Expression of AE2 anion exchanger in mouse intestine.
We have characterized expression of anion exchanger 2 (AE2) mRNA and protein in the mouse intestine. AE2 mRNA abundance was higher in colon than in more proximal segments. AE2a mRNA was more abundant than AE2b mRNA throughout the intestine, and AE2c mRNA was expressed at very low levels. This AE2 mRNA pattern contrasted with that in mouse stomach, in which AE2c > AE2b > AE2a. AE2 polypeptide ab...
متن کاملAE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon.
Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na(+)-K(+)-2Cl(-) cotransporter mediates basolateral Cl(-) uptake. However, additional evidence suggests that the AE2 Cl(-)/HCO(3)(-) exchanger, when coupled with the NHE1 Na(+)/H(+) exchanger or a Na(+)-HCO(3)(-) cotransporter (NBC), contributes...
متن کاملImmunolocalization of AE2 anion exchanger in rat kidney.
The cellular and subcellular localizations of the AE2 anion exchanger in rat kidney have remained elusive despite detection of moderately abundant AE2 mRNA and AE2 polypeptide in all kidney regions. In this report a simple epitope unmasking technique has allowed the immunolocalization of AE2 antigenic sites in basolateral membranes of several rat kidney tubular epithelial cells. AE2 immunostain...
متن کاملTissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene.
Previously, we isolated the human AE2 (SLC4A2) gene, a member of the sodium-independent anion exchanger family. Rat ortholog of this gene was reported to drive alternative transcription yielding N-terminal variants of the AE2a message. We thus analyzed the human AE2 gene in this regard. Using HepG2 cells, two alternative first exons, each splicing to exon 3 in alternative transcripts, were foun...
متن کاملChromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3.
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129, USA Department of Internal Medicine, University of Michigan, 1560 MSRB II, 1150 West Medical Center Drive, and Ann Arbor Veterans Administration Hospital, Ann Arbor, Michigan, 48109, USA Department of Molecular Biology, Université Libre de Bruxelles, Rhode-St-Genese, Bel...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2008
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2007.09.006